[Laysan Bio 공식대리점 관련 업무대행/수입] MAL-PEG-SVA

[Laysan Bio 공식대리점 관련 업무대행/수입] MAL-PEG-SVA

[MAL-PEG-SVA]

Product Description:

Maleimide-PEG-SVA (Succinimidyl Valerate)는 PEG chain의 한쪽 끝에 maleimide group을, 다른 쪽 끝에 succinimidyl valerate group을 결합한 heterobifunctional 화합물입니다. 이 독특한 구조 덕분에 thiol (-SH) 및 amine (-NH2) 그룹 모두와 반응할 수 있어 다양한 생체접합 응용 분야에서 매우 다용도로 활용됩니다.

Key Features:.

• Polyethylene Glycol (PEG) Spacer: Provides hydrophilic properties, enhancing water solubility and reducing immunogenicity.
• Succinimidyl Valerate (SVA) Group: Reacts with primary amines to form stable amide bonds.  
• Maleimide Group: Reacts with thiols to form stable thioether bonds.

Applications:

• Protein-protein conjugation: Crosslinking proteins with specific thiol and amine groups.
• Protein-drug conjugation: Attaching drugs to proteins for targeted delivery.
• Antibody-drug conjugates: Connecting therapeutic agents to antibodies for cancer treatment.
• Bioconjugation of biomolecules: Modifying enzymes, peptides, and nucleic acids with various functional groups.  
• Nanomaterial functionalization: Attaching biomolecules to nanoparticles for biomedical applications.  

Advantages:

• High reactivity: Reacts with both thiol and amine groups under mild conditions.
• Water solubility: The PEG spacer improves water solubility, enhancing biocompatibility.
• Stability: The formed thioether and amide bonds are stable, ensuring long-lasting conjugation.

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